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Furthermore, ED could be a sign of underlining health issues physical, psychological, or a mixture of both. Nelson CJ, Mulhall JP, Roth AJ The association between erectile dysfunction and depressive symptoms in men treated for prostate cancer. Rare side effects of all PDE5 inhibitors include a sudden loss of vision in one or both eyes nonarteritic anterior ischemic optic neuropathy and sudden loss of hearing. Those against circumcision point out that after the process, the glans is left uncovered and can lose a great deal of its sensitivity, limiting sexual response. The process of seminal fluid discharge is called the ejaculation.